Barkley Shut Up and Jam! is a basketball video game originally developed and published by Accolade for the Sega Genesis on North America in 1993 and later in Europe in April 1994. It is the first entry in the Barkley Shut Up and Jam series, featuring former NBA MVP Charles Barkley prominently and as one of the playable characters.

Featuring arcade-style gameplay similar to Midway's NBA Jam but closely following the rules seen in street basketball, players compete with either CPU-controlled opponents or against other players in matches across various cities of the United States. Originally known as Charles Barkley Basketball during development and initially released on the Genesis, it was later ported to the Super Nintendo Entertainment System and first released on North America in June 1994 and this version was released months later in both Japan and Europe on the same year by Den'Z and Sony Electronic Publishing respectively.

Barkley Shut Up and Jam! received mixed but positive reception when it was released on both platforms, with reviewers praising the graphics, sound and multiplayer, while others criticized the controls, lackluster animations and gameplay, with critics also comparing the game with NBA Jam. Ports for the PC and Atari Jaguar were in development but never released. A sequel, Barkley Shut Up and Jam 2, was exclusively released for the Genesis in 1995.